nir-vana innovation network

Biocatalysis is a powerful tool which allows the synthesis of almost any kind of chiral or nonchiral compound. Compared to traditional organic synthesis, enzymes reduce the necessary steps of a transformation, thereby lowering the number of intermediates which leads to less chemical waste and resource consumption. Additionally, enzymes usually work at mild, environmentally friendly conditions and are a green alternative to chemical catalysts that usually incorporate rare heavy metals and need energy consuming process conditions.

A German-Sino bio-engineering company offers a proprietary enzyme engineering platform to optimize biocatalytic transformations in industrial processes. The company offers R&D service platform, guiding the customer from the initial idea all the way to the industrial biocatalytic process.

The company guides this process with an international team of highly experienced scientists applying the latest state of the art technologies. Using their comprehensive experience in directed enzyme evolution, strain engineering, fermentation process development and commercial scale biocatalytic production, they successfully apply a proprietary R&D platform to develop novel, optimized enzyme technologies. This enzyme directed evolution platform is innovated by the integration of bioinformatic database guided design, computer modelling and simulations, as well as state of the art high throughput screening systems.

The platform was established in 2015 and has been successfully applied to almost 150 projects. Each process step is continuously monitored and evaluated and further developed and optimized.

It provides services for various fields of application, such as the fine chemical, food, pharmaceutical, and material industries. The development of enzymatic technology for feed, environmental and waste treatment industries is also being explored.

The company is looking for industrial and academic partners from various fields, which are either seeking new synthetic routes for specific fine, pharmaceutical and commodity chemicals or options to optimize existing processes by implementing enzymatic transformations. A research cooperation is envisaged.
The biotech company is furthermore open to other kinds of cooperation.

Advantages & innovations

The German-Sino bio-engineering company has developed a proprietary protein engineering platform combing computational enzyme engineering with directed evolution, resulting in several advantages: • The combination of in silico prescreening and focused library design provides a high sequence coverage while dramatically reducing the library size and required experimental time. • π2.0 supercomputer account allows for time efficient and parallel handling of multiple computer aided enzyme evolution projects. • Thorough analysis with HPLC /GC (high performance liquid chromatography / gas chromatography) methods provides comprehensive reaction insights on all components of the reaction. • Application of the desired final process conditions during the entire enzyme development allows easy transfer of the finalized process. • The optimized, engineered enzymes are high performance catalysts that meet the requirements of each unique industrial process, from enantioselectivity to solvent stability. • The developed enzymatic processes enable the manufacturing of a broad spectrum of optically pure products for all kinds of industries.

Stage of development

Already on the market

Partner sought

The company is looking for industrial and academic partners from the fields pharma, food and feed, fine chemicals, consumer goods and others. Therefore the company provides a comprehensive enzyme technology plattform for the partner's R&D projects, e.g., for new synthetic processes towards fine and pharmaceutical chemicals or optimization of existing processes. Hence a research cooperation is envisaged. The company is also open to other types of cooperation.