Focus on improving our planet.
Let's collaborate for sustainability &
digitalization.

Open innovation Platform for sustainability.
Find the right opportuinty and grow up your
innovation ecosystem.

Sign in/up

Search an
opportunity

Do you want to be part of innovative a sustainable project? Search for your opportunity and make your contribution to for the sustainable growth of the economy and the planet.

Tech collaborations
Joint Ventures
Licensing
Subcontracting
Investment

Express interest
German university research institute is looking for develope...
created · Updated
Deadline: Jan 9, 2022
Received 0 expressions of interest

Summary

A German research institute wants to use its cell and ex vivo tissues as platform to test connexin (Cx) hemichannel inhibitors as drugs for the treatment of chronic inflammation-related diseases. Cxs form cell-to-cell channels between adjacent cells as well as hemichannels in single cells. Cx hemichannels are upregulated during inflammation and participate to further release of injury signals. The institute is looking for laboratories and companies to develop and test potential inhibitors.

Description

The German research institute has established a basis platform of cells and ex vivo tissues to analyse the upregulation of specific connexin hemichannels induced by the inflammation-initiators and inflammation-mediators. With this system it is possible to analyse the upregulation of connexin hemichannels in cells of different tissues. This platform can be used to develop connexin hemichannel inhibitors as drugs for treatment of chronic inflammation-related diseases such as morbus Crohn or colitis in the intestine as well as cystic fibrosis (CFTR), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma in the airway, various neurodegenerative diseases like amyotrophic lateral sclerosis (ALS),Alzheimer or multiple sclerosis and other impairments like age-related muscle degeneration.

The research institute has a long expertise in connexin physiology in various tissues such as the vascular system. Moreover the research institute has recently implemented a culture of epithelial cells on porous membranes in transwell systems. The culture allowed the cell to form a good barrier and to consider the polarized expression of the receptors and the resulting effect on the connexin channels. Moreover the system should also be used to introduce other cells in a co-culture system allowing the simulation of the in vivo situation. Co-cultures and ex vivo tissue models can be used to evaluate the role of identified mediators and connexins in the inflammation related impairments.

Based on the current results and analysed cell systems, the involvement of Cx hemichannels should be characterized in the cellular response to bacterial toxins and markers, the so called inflammation initiators, as well as the inflammation mediators, such as cytokines or metabolites like nicotinamide adenine dinucleotide, nucleotides and oligonucleotides.

The research institute is looking for chemical laboratories and pharmacological companies, which provide connexin hemichannel inhibitors to be tested with the developed cell and ex vivo model system. Possible types of partnership include but are not limited to a joint venture agreement, a research cooperation agreement or a technical cooperation agreement.

Advantages & innovations

GERMANY

Stage of development

GERMANY

Partner sought

Based on the above described system the research institute is looking for and would like to cooperate with chemistry laboratories and pharmacological companies to develop and test inhibitors to specifically inhibit connexin hemichannels. The inhibitors can have potential for further development in drugs for treatment of inflammation related impairments.

Create an
opportunity

Show your project-opportunity to generate interest of potential partners or collaborators. Companies, freelancers, or research centers can meet in Nir-vana and become perfect team together!

Latest Opportunities
Project full name: EIT Food Public Engagement Proof of Concepts Call for Proposals 2023, 2024, 2025
Project acronym: EIT Food PE PoC Call 2023, 2024, 2025
Grant agreement number: N/A
Total EU funding available: €360 000 per submission window (total for 3 rounds: €1 380 000)
By the date of the Calls’ launches a webpage will be activated at eitfood.eu/projects/public-engagement-proof-of-concepts-call

Join and create
your ecosystem

Meet and connect with experts from around the world. Generate your innovative ecosystem and interact with them thanks to the different functionalities of Nir-vana: exchange spaces, lists of opportunities, expression of interest

M.Ayhan Çobanlıoğlu
Timo Huttunen
Build your project with
the best professionals
in the sector
Latest Opportunities
    Project full name: EIT Food Public Engagement Proof of Concepts Call for Proposals 2023, 2024, 2025
    Project acronym: EIT Food PE PoC Call 2023, 2024, 2025
    Grant agreement number: N/A
    Total EU funding available: €360 000 per submission window (total for 3 rounds: €1 380 000)
    By the date of the Calls’ launches a webpage will be activated at eitfood.eu/projects/public-engagement-proof-of-concepts-call
    Company based in Sweden, is a pioneering force in digital cleaning training, specializing in e-learning for cleaners, supervisors, and clients. With a proven track record since 1994 and a recent foray into international markets, companyseeks strategic partnerships in Europe.

    Comprehensive Business Solutions promoting EU and Central Africa

    published
    Deadline: Dec 13, 2024
    The company promotes trade and investment between Slovenia, Cameroon, the EU, and Central Africa. They offer a comprehensive suite of business solutions including consultancy across all aspects of operations, data-driven market feasibility studies to inform business decisions, and customized software development to streamline processes and increase efficiency.
    Spanish company manufacturing vinegars, lemon juice, food dressings, balsamic creams and other related products in different types of containers and different formats and weights, is looking for wholesaler or distributor. Preferred channels: supermarkets, large distribution, convenience stores, hospitality services (hotels, restaurants and catering), gourmet shops and others.
Public Spaces
  • Vivalanch Electronic and Automation Comp.
    We is offer consumers cutting-edge, superior, and specialize...
  • TOW - AWAY
    The tow-away is an IT tool that allows the digitization of t...
  • BUS4U - Monitoring of urban public transport
    BUS4U is the research project for the monitoring and control...

The most relevant open & connected
network for sustainable business development.

Join now!

Sustainable
projects

Nir-vana wants to be the first open innovation platform focus on sustainability.

According to the EU Action Plan there is a huge need of change to a more sustainable future and to collaborate and assure to achieve the SDG.

Network
& experts

Nir-vana is the only platform integrating seamless "search and find" to the next stage of collaborating.

Get connected with experts and companies for partnering. Find trusted innovation advisors, certified by Enterprise Europe Network and build up your team of partners, companies and experts you need for your innovation.

Find public funding &
private investors

Discover potential funding opportunities for your innovation. On nir-vana you have access to national and EU funding programmes, public funding and private investors.

Get connected to consultants and advisors specialised on funding and grant preparation.